Endocrine Abstracts

Medulloblastoma is the most common malignant brain tumor in childhood. Treatment of medulloblastoma includes surgery, radiation therapy and chemotherapy. Craniospinal radiation can cause adverse effects on the endocrine system, specifically on the hypothalamic-pituitary axis. Increasing survival rates of pediatric patients with brain tumors lead to increased concern regarding long-term quality of life, including the detection and correction of endocrine disorders. One of the m...

IntroductionAmiodarone is a drug commonly used for the treatment of refractory atrial or ventricular arrhythmias. In 20% of patients, amiodarone may cause subclinical or clinically overt hypothyroidism or hyperthyroidism. The high iodine exposure caused by amiodarone treatment interferes with thyroid autoregulation. Two underlying mechanisms are considered to be involved in the pathogenesis of amiodarone-induced thyrotoxicosis (AIT). AIT1 is more common ...

Coexistence of different types of brain tumors is a very rare condition. We present a clinical case of PRL-secreting adenoma and germ cell tumor coexistence in 14-year-old adolescent. The patient was admitted to our Center with complaints of headache with nausea episodes, left-sided ptosis. Visual acuity was: visus OD=1.0; visus OS=0.6 Cyl -0.5 ax 70=1.0. Neuroimaging revealed supra-para(D,S) sellar mass 39×32×21 mm. Laboratory data revealed hypothyroidism, hypocorti...

Children and adolescents treated for solid brain tumors with chemotherapy and craniospinal irradiation are at increased risk of metabolic changes development. Current follow-up guidelines for cancer survivors recommend to monitor fasting glucose and HbA1 levels for diabetes/impaired glucose tolerance screening in these patients. The aim of our study was to evaluate metabolic changes in children treated for medulloblastoma with oral glucose tolerance test (OGTT). We examined 63...

Hypercortisolism due to Cushing disease is an extremely rare condition in children under one year of age. We present a case of a 10-month-old boy with lung cystic dysplasia and pituitary blastoma (ACTH-secreting). The disease manifested with symptoms of hydrothorax due to cystic dysplasia of the right lung’s upper lobe. Surgical resection of the affected area has been carried out. Symptoms of endogenous hypercortisolism appeared soon after lung surgery. Cushing disease du...

X-linked acro-gigantism (X-LAG) is a rare novel genomic syndrome of pituitary gigantism that has a typical onset within the first year of life in children of normal or even low birth weight. X-LAG patients have a microduplications on chromosome Xq26.3 that includes a gene GPR101, which is highly upregulated in pituitary tumor tissue of affected patients. We performed a study of all 18 known X-LAG syndrome patients currently in the NICHD-University of Liège databa...